It depends on your policy.

The best thing is to review your policy, or ask your insurance agent to review it with you. Your policy may cover autos rented for pleasure, like vacations or special events, but not business.

If you do not have comprehensive and collision coverage (often referred to as "physical damage coverage") for your own car, you may not have coverage for a rental car. And if you damage a rental car, your policy may not cover lost revenue the rental car company incurs while the rental car is being fixed; or the cost of a new car if you total the rental.