In almost all states the answer to this question is yes. If you are on vacation or just visiting friends out of state when the DUI happens, you are still going to be on the hook back home.
A second DUI in another state can have a major impact on your home state record. As an example, say you live in Maine and had a DUI a couple of years ago but then received another DUI in Iowa. While Iowa would treat this as a first DUI, once Iowa reports to Maine, then Maine will consider it a second DUI offense and will suspend your license for three years, which is the penalty for a second offense in Maine.
If you have a DUI on your record, read our guide on DUI insurance to learn how to minimize the damage and get back on the road, paying affordable insurance rates, sooner than later.